ParkinsonFranceV1, PubMed, Checkpoint, bibRecord, 001495

Effect of parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation.

Identifieur interne : 001495 ( PubMed/Checkpoint ); précédent : 001494; suivant : 001496

Effect of parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation.

Auteurs : P. Limousin [France] ; P. Pollak ; A. Benazzouz ; D. Hoffmann ; J F Le Bas ; E. Broussolle ; J E Perret ; A L Benabid

Source :

Lancet (London, England) [ 0140-6736 ] ; 1995.

RBID : pubmed:7815888

English descriptors

KwdEn :
- Electric Stimulation Therapy (adverse effects), Electrodes, Implanted, Humans, Male, Middle Aged, Movement Disorders (therapy), Muscle Rigidity (therapy), Parkinson Disease (therapy), Thalamic Nuclei.
MESH :
- adverse effects : Electric Stimulation Therapy.
- therapy : Movement Disorders, Muscle Rigidity, Parkinson Disease.
- Electrodes, Implanted, Humans, Male, Middle Aged, Thalamic Nuclei.

Abstract

In monkeys rendered parkinsonian, lesions and electrical stimulation of the subthalamic nucleus reduce all major motor disturbances. The effect of electrical stimulation of the subthalamic nucleus was assessed in three patients with disabling akinetic-rigid Parkinson's disease and severe motor fluctuations. Quadripolar electrodes connected to a pulse generator were implanted in the subthalamic nuclei on both sides. Patients were evaluated with the unified Parkinson's disease rating scale and timed motor tests. 3 months after surgery, activities of daily living scores had improved by 58-88% and motor scores by 42-84%. This improvement was maintained for up to 8 months in the first patient operated upon. One patient was confused for 2 weeks after surgery, and another developed neuropsychological impairment related to a thalamic infarction which improved over 3 months. In one patient, stimulation could induce ballism that was stopped by reduction of stimulation. This is the first demonstration in human beings of the part played by the subthalamic nuclei in the pathophysiology of Parkinson's disease.

PubMed: 7815888

Affiliations:

France

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pubmed:7815888

Le document en format XML

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<author><name sortKey="Limousin, P" sort="Limousin, P" uniqKey="Limousin P" first="P" last="Limousin">P. Limousin</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University of Grenoble, France.</nlm:affiliation>
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<author><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P" last="Pollak">P. Pollak</name>
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<author><name sortKey="Hoffmann, D" sort="Hoffmann, D" uniqKey="Hoffmann D" first="D" last="Hoffmann">D. Hoffmann</name>
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<author><name sortKey="Le Bas, J F" sort="Le Bas, J F" uniqKey="Le Bas J" first="J F" last="Le Bas">J F Le Bas</name>
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<author><name sortKey="Broussolle, E" sort="Broussolle, E" uniqKey="Broussolle E" first="E" last="Broussolle">E. Broussolle</name>
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<author><name sortKey="Perret, J E" sort="Perret, J E" uniqKey="Perret J" first="J E" last="Perret">J E Perret</name>
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<author><name sortKey="Benabid, A L" sort="Benabid, A L" uniqKey="Benabid A" first="A L" last="Benabid">A L Benabid</name>
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<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en">In monkeys rendered parkinsonian, lesions and electrical stimulation of the subthalamic nucleus reduce all major motor disturbances. The effect of electrical stimulation of the subthalamic nucleus was assessed in three patients with disabling akinetic-rigid Parkinson's disease and severe motor fluctuations. Quadripolar electrodes connected to a pulse generator were implanted in the subthalamic nuclei on both sides. Patients were evaluated with the unified Parkinson's disease rating scale and timed motor tests. 3 months after surgery, activities of daily living scores had improved by 58-88% and motor scores by 42-84%. This improvement was maintained for up to 8 months in the first patient operated upon. One patient was confused for 2 weeks after surgery, and another developed neuropsychological impairment related to a thalamic infarction which improved over 3 months. In one patient, stimulation could induce ballism that was stopped by reduction of stimulation. This is the first demonstration in human beings of the part played by the subthalamic nuclei in the pathophysiology of Parkinson's disease.</div>
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<Abstract><AbstractText>In monkeys rendered parkinsonian, lesions and electrical stimulation of the subthalamic nucleus reduce all major motor disturbances. The effect of electrical stimulation of the subthalamic nucleus was assessed in three patients with disabling akinetic-rigid Parkinson's disease and severe motor fluctuations. Quadripolar electrodes connected to a pulse generator were implanted in the subthalamic nuclei on both sides. Patients were evaluated with the unified Parkinson's disease rating scale and timed motor tests. 3 months after surgery, activities of daily living scores had improved by 58-88% and motor scores by 42-84%. This improvement was maintained for up to 8 months in the first patient operated upon. One patient was confused for 2 weeks after surgery, and another developed neuropsychological impairment related to a thalamic infarction which improved over 3 months. In one patient, stimulation could induce ballism that was stopped by reduction of stimulation. This is the first demonstration in human beings of the part played by the subthalamic nuclei in the pathophysiology of Parkinson's disease.</AbstractText>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Effect of parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation.

Effect of parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki